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KMID : 0948920130120020066
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Clinical Pain
2013 Volume.12 No. 2 p.66 ~ p.74
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Management of Neuropathic Pain: Guide-lines for Medications and Role of Exercise
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Park Yun-Hee
Sung Duk-Hyun
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Abstract
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Neuropathic pain is a result of complex interaction between peripheral and central mechanisms with multiple therapeutic targets. A number of different treatments for neuropathic pain have been studied, and several recommendations offer in-sight into managing neuropathic pain. The analgesics com-mon to these guidelines are secondary amine tricyclic anti-depressants, serotonin and norepinephrine reuptake in-hibitors, calcium channel α2-δ ligands, topical lidocaine, tramadol, and opioid antagonists. Exercise may positively influence the pathological factors associated with neuro-pathy by promoting microvascular dilation, reducing oxida-tive stress, and increasing neurotrophic factors, but it is un-known whether exercise will improve or worsen neuropathic pain. The objectives of the current article are to review re-cent guidelines for the pharmacological management of neuropathic pain and to provide a brief overview for role of exercise for neuropathic pain
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KEYWORD
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Neuropathic pain, Pharmacological management, Evidence-based recommendations, Exercise
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